ESRI Congress – 2022, ParisFor Details Click Here…….
XIV Congress of the International Society for Immunology of Reproduction (ISIR) hosted by JAPAN Society for Immunology of Reproduction will be held at Nara, Japan in the year 2019. Nara is an old capital in Japan, and there are many temples and shrines. It has very easy access from Kansai – Osaka airport.
For further information please contact Prof. Shigeru Saito
Professor and Chairman
Department of Obstetrics & Gynaecology
Graduate School of Medicine and Pharmaceutical Science and Research
Faculty of Medicine
University of Toyama
2630 Sugitani, Toyama 930-0194
Japan
Tel +81 76 434 7355
Fax +81 76 434 5036
E-mail: s30saito@med.u-toyama.ac.jp
Introduction of Books Published by the Members
Immunology of Pregnancy 2013
Editors; Gérard Chaouat, Olivier Sandra and Nathalie LedeeSince a September, 1992, Nature article which read: “Can there be life without LIF?”, researchers now realize that the maternal immune system is both a foe (it can reject the conceptus) and a friend (immune cells and molecules are also necessary for successful pregnancy). Leukemia Inhibitory Factor (LIF) when absent, prevents embryo implantation in rodents. From fecundation to parturition, immunity acts as a Janus, required but potentially dangerous. However, the complexity and the diversity of immunity in pregnancy deter many from entering the field. This book will try to give a complete overview of immunity from gametes till parturition, in brief, but with complete chapters and subsections, each written by leading specialists in the field.The importance of the topic relies not only on “the riddle of the fetal allograft”, which is per se fascinating, but on its consequences, linked to the development of IVF and in general, Assisted Reproductive Technologies (ART) / Medicine. Since the discovery that there would not be (mammalian) life without LIF, it has become clear that in general, Immune Molecules, and most specifically a transient post mating inflammatory reaction are required for successful implantation. Disruptions of this process can lead to implantation failure / sterility.
In later stages of pregnancy immunological cells, mostly of the innate immune system, control formation of local spiral arteries. Finally, a state of tolerance establishes itself, whose “break” leads to immune abortion. Also the vascular bed is further transformed and enlarged, till delivery, and here again “immunological cytokines” do play a major role and can eventually cause immune mediated abortion.
Failure of, not just, the cytokine and cell recognition mediated dialogue, but also of the pre and peri-implantation “preparation of the uterus”, as stated, leads to sterility, early pregnancy loss and recurrent abortions. There is also an increasingly stronger series of argument to implicate immunology in pre-eclampsia. Further still, immunology is also implicated in the control of local infection, mother to child transmission of pathogens (notably, but not limited to, HIV). Finally, pregnancy is the only known physiological allorecognition phenomenon where the once named “suppressor T cells,” now re-emerged as “regulatory T cells”, play a cardinal role.
This E-book provides a complete compendium of gynecological immunology, spanning from fecundation to delivery. Topics also include the role of various cell types (such as T regs and NK cells) in implantation and uterine changes as well as the genetic regulation of immunological processes. As such it will be of interest not only to mainstream and reproductive immunologists, but more importantly, clinicians in obstetrics and gynecology.
Contents
1. Innate and Adaptive Immunity in the Human Female Reproductive
Tract: Bridging the Menstrual Cycle with Pregnancy
Charles R. Wira, Mickey V. Patel, Mimi Ghosh and Zheng Shen,
Marta Rodríguez-García
2. Immunity and Sperm: Auto- and Iso Immunization
Koji Koyama
3. Contraceptive Vaccines: Past, Present and Future
Satish K. Gupta
4. Immune Markers of Oocyte and Embryo Quality
Nathalie Lédée
5. MHC Antigens Expression/ Function at the Embryonic Interface
Part A: Major Histocompatibility Complex Class I Unique Expression in Human Trophoblast: Facts, Questions and Controversies
Philippe Le Bouteiller
Part B: Expression of MHC-I Proteins by the Placenta of Domestic and Laboratory Animals
Heloisa M. Rutigliano, Aaron J. Thomas and Christopher J. Davies
6. Immunology of Implantation, Implantation Failure and Pregnancy
Part A: Regulators of Early Invasion of Trophoblast Cells
Pankash Shuman and Satish K. Gupta
Part B: Dendritic Cells: New Insights in Reproduction
Sandra M. Blois, Petra C. Arck and Gabriel Barrientos
Part C: A Summary of Cytokine Networks and Embryo: A Short Overview
Gerard Chaouat
Part D: Human Implantation
Nathalie Lédée and Mona Rahmati
Part E: Interleukin-10: A Vascular and Anti-Inflammatory Cytokine Connecting the Pieces of the Pregnancy Puzzle
Satyan Kalkunte, Tania Nevers, Eliana Lippe and Surendra Sharma
Part F: Functional Duality of Mouse Uterine Natural Killer Cell
in Pregnancy
Patricia D.A. Lima, Valdemar A. Paffaro Jr. and Aureo T. Yamada
Part G: Human Uterine Natural Killer Cells. Friend or Foes of Pregnancy Outcomes
Eliana M O Lippe, Aureo T Yamada and Surendra Sharma
Part H: Factors Elevated during Sexual Intercourse Act to Assist Pregnancy Outcome
Mukesh K. Jaiswal, Timothy M. Millers, Alice Gilman-Sachs and
Kenneth D. Beaman
Part I: Substances Secreted by the Preimplantation Human Embryo
Georgi Georgiev, Jana Pastuschek, Stefan Neubeck and Udo R. Markert
Part J: Placental Interferons, Implantation and Pregnancy
Fuller W. Bazer
Part K: Pathophysiology of the Complement System at Feto-Maternal Interface
Roberta Bulla, Chiara Agostinis and Francesco Tedesco
Part L: Toll-like Receptors and Nod-Like Receptors in Gestational Tissues
Vikki M. Abrahams
7. Tolerance to the Fetal Allograft
Part A: Is the Fetus an Allograft and is it Object of Immunological Tolerance?
Gérard Chaouat
Part B: Immunoregulation at the Interface by Placental Suppressor Factors
Gérard Chaouat
Part C: Decidual Transforming Growth Factors and Tolerance Signalling Molecules
David A. Clark and Reginald M. Gorczynski
Part D: Role of Regulatory T Cells in Human Reproduction
Leonardo Fainboim
Part E: the Role of Cytotoxic Natural Killer (NK) Cells and Regulatory NK Cells in Pregnancy
Shigeru Saito, Tomoko Shima, Akitoshi Nakashima and Yi Lin
Part F: Pathways for Activating Implantation Tolerance in Early Pregnancy
Sarah A. Robertson, David J. Sharkey, John E. Schjenken, Alison S.
Care and Lachlan M. Moldenhauer
8. Immuno Endocrine Interactions: An Example
Progestagen Treatment for Threatened and Recurrent Abortion; Molecular
Mechanisms
Julia Szekeres-Bartho, Melinda Halasz, Beata Polgar and Agnes
Bogdan
9. The Maternal Inflammatory Response to Pregnancy
Jennifer H. Southcombe and Ian L. Sargent
10. Are there Abortions of Immunological Origin?
Part A: Animal Models of Spontaneous Immunological
Abortions
Gérard Chaouat
Part B: Immunology and Recurrent Pregnancy Loss. Epidemiological Aspects in Humans
Ole B. Christiansen
Part C: Immune Treatments Recent Developments
Edward E. Winger and Jane L. Reed
Part D: Debates on Immunotherapy for Recurrent Pregnancy
Failure
David A. Clark
Part E: Debates on Immunotherapy for Recurrent Pregnancy
Failure
Gérard Chaouat
11. Impact of the Immune System on Trophoblast Invasion and
Uteroplacental Blood Flow
Raj Raghupathy
12. Epidemiology and Immunology of Preeclampsia
Part A: Preeclampsia, Plague of Human Reproduction. The Role of Paternity and Immunological Implications
Pierre-Yves Robillard and Gustaaf Dekker
Part B: Animal Models for a Cure for Preeclampsia
Guillermina Girardi
13. Autoimmunity in Association with Pregnancy
Nobert Gleicher
14. The Control of HIV-1 In Utero Transmission at the Materno-Foetal Interface by Immunological Determinants
Héloïse Quillay, Romain Marlin, Marion Duriez, Marie-Thérèse
Nugeyre and Elisabeth Menu
Annex 1: Immunology for Assisted Reproductive Medicine
Practitioners: A Comprehensive Overview
Ae-Ra Han, Alice Gilman-Sachs, Joon W. Kim and Joanne Kwak-
Kim.
Annex 2: Glossary
Conclusion
Gérard Chaouat